Use of flutamide for self-induced androgen excess. A case report.

A 28-year-old woman developed hirsutism, facial edema and clitoromegaly after self-injection of long-acting synthetic androgens. The symptoms were ameliorated by administration of flutamide with a combination oral contraceptive. Flutamide appears to be useful in preventing sequelae of acute androgen excess in women and may be a rational therapy for chronic treatment of androgen excess in women.