Cell reports. Medicine · 2024
Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kanth Shreya M, Huapaya Julio A, Gairhe Salina, Wang Honghui, Tian Xin, Demirkale Cumhur Y, Hou Chunyan, Ma Junfeng, Kuhns Douglas B, Fink Danielle L, Malayeri Ashkan, Turkbey Evrim, Harmon Stephanie A, Chen Marcus Y, Regenold David, Lynch Nicolas F, Ramelli Sabrina, Li Willy, Krack Janell, Kuruppu Janaki, Lionakis Michail S, Strich Jeffrey R, Davey Richard, Childs Richard, Chertow Daniel S, Kovacs Joseph A, Parizi Parizad Torabi-, Suffredini Anthony F, COVID-ARC Study Group
Аннотация
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases (acute, recovery, and convalescent) are evaluated over a year. During the acute phase, inflamed and uninflamed phenotypes are characterized by the expression of tissue repair and host defense response molecules. With recovery, inflammatory and fibrogenic mediators decline and clinical symptoms abate. However, at 9 months, quantified radiographic abnormalities resolve in the majority of patients, and yet compared to healthy persons, all showed ongoing activation of cellular repair processes and depression of the renin-kallikrein-kinin, coagulation, and complement systems. This dissociation of prolonged reparative processes from symptom and radiographic resolution suggests that occult ongoing disruption of the lung proteome is underrecognized and may be relevant to recovery from other serious viral pneumonias.