Open veterinary journal · 2025
Combined extracts of Curcuma longa and Curcuma zedoaria ameliorates cisplatin-induced kidney damage in rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Intan Putri Reno, Alegantina Sukmayati, Fajri Hidayatul, Ekawasti Fitrine, Isnawati Ani, Lienggonegoro Lisa Andriani, Nikmah Uly Alfi, Sunarno Sunarno, Mariya Sela Septima, Sutardi Lina Noviyanti, Setiyono Agus, Handharyani Ekowati
Аннотация
BACKGROUND: Cisplatin (CIS) is a highly effective chemotherapeutic drug. However, it is associated with various side effects, including kidney damage, due to its nephrotoxic properties.
AIM: This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on tumor necrosis factor-alpha (TNF-α), KIM-1, and caspase-3 levels.
METHODS: Twenty-five rats were divided into normal control groups (NS), CIS control groups, and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively, on day 1-20. All groups, except the NS group (receiving normal saline i.p.), received intraperitoneal CIS (1 mg/kg) on days 7 and 14 of the 20-day extract treatment.
RESULTS: Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, exerted the most apparent protective effect, decreasing renal TNF-α, KIM-1, and caspase 3.
CONCLUSION: The combined extract of C. longa and C. zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans.
AIM: This study aimed to evaluate the renoprotective potential of the combined extract of Curcuma longa and Curcuma zedoaria in reducing nephrotoxicity by examining its effects on tumor necrosis factor-alpha (TNF-α), KIM-1, and caspase-3 levels.
METHODS: Twenty-five rats were divided into normal control groups (NS), CIS control groups, and three treatment groups that received doses of the combined extract at 100, 200, and 400 mg/kg (CUR100, CUR200, and CUR400), respectively, on day 1-20. All groups, except the NS group (receiving normal saline i.p.), received intraperitoneal CIS (1 mg/kg) on days 7 and 14 of the 20-day extract treatment.
RESULTS: Compared with the rats in the CIS group, rats given the combined extract had a considerable gain in body weight and decreased TNF-α, KIM-1, and caspase-3 expression levels. Histopathological examination revealed that the extract group experienced less kidney damage than the CIS group. The combined extract, administered at 200 mg/kg, exerted the most apparent protective effect, decreasing renal TNF-α, KIM-1, and caspase 3.
CONCLUSION: The combined extract of C. longa and C. zedoaria has the potential to be a therapeutic agent for reducing nephrotoxicity by suppressing TNF-α, KIM-1, and caspase-3 levels. Further research is required to determine the potential of this combination therapy in humans.