Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates.
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Jatana Sukhdeep, Verhoeff Kevin, Wang Yanbo, Wang Zhicheng, Zhou Jiale, Wu Xiaorong, Chen Yonghui, Śledziński Maciej, Hellmann Andrzej, Raffaelli Marco, Pennestrì Francesco, Sywak Mark S, Papachristos Alexander, Palazzo Fausto F, Sung Tae Yon, Kim Byung-Chang, Lee Yu-Mi, Eatock Fiona, Anderson Hannah, Iacobone Maurizio, Gray Daryl K, Chaulk Richard C, Kosmoliaptsis Vasilis, Colucci Nicola, Spiers Harry V M, Daukša Albertas, Makay Özer, Türk Yiğit, Basut Atalay Hafize, Nieveen van Dijkum Els J M, Engelsman Anton F, Holscher Isabelle, Materazzi Gabriele, Rossi Leonardo, Becucci Chiara, Shore Susannah L, Fung Claire, Waghorn Alison, Mihai Radu, Balasubramanian Sabapathy, Pannu Arslan, Tatarano Shuichi, Velázquez-Fernández David, Miller Julie A, Serrao-Brown Hazel, Chen Yufei, Demarchi Marco Stefano, Djafarrian Reza, Doran Helen, Stechman Michael J, Perry Helen, Hubbard Johnathan G H, Lamas Cristina, Mercer Philippa, MacPherson Janet, Lumbiganon Supanut, Calatayud María, Hanzu Felicia Alexandra, Vidal Oscar, Araujo-Castro Marta, Minguez Ojeda César, Papavramidis Theodosios, Rodríguez de Vera Gómez Pablo, Aldrees Abdulaziz, Altwjry Tariq, Valdés Nuria, Álvarez-Escola Cristina, García Sanz Iñigo, Blanco Carrera Concepción, Manjón-Miguélez Laura, De Miguel Novoa María Paz, Recasens Mónica, García-Centeno Rogelio, Robles Lázaro Cristina, Van Den Heede Klaas, Van Slycke Sam, Michalopoulou Theodora, Aspinall Sebastian, Melvin Ross, Wen Liang Lau Joel, Cheah Wei Keat, Tang Man Hon, Oh Han Boon, Ayuk John, Parente Alessandro, Sutcliffe Robert P, International Pheo Study Group
Аннотация
METHODS: A retrospective international multicenter cohort study was performed on patients undergoing adrenalectomy for pheochromocytoma between 2012 and 2022 in 49 centers. Patients were divided into three cohorts: ≤40, 41-59, and ≥60 years old. Univariate and multivariate analyses were used to compare cohorts and assess the impact of age on postoperative outcomes.
RESULTS: Of the 2,301 included patients, 551 were ≤40 years (23.9%), 969 were between 41 and 59 years (42.1%), and 781 were ≥60 years (33.9%). Younger cohorts were more likely to have a genetic syndrome (≤40 years 29.4% vs 41-59 years 11.5% vs ≥60 years 6.2%, P < 0.001) and bilateral tumors (10.2 vs 2.3 vs 1.3%, P < 0.001). On multivariable analysis, overall complications seemed less frequent in older cohorts (adjusted odds ratio (aOR): 0.64, P = 0.012, and aOR: 0.66, P = 0.054, for 41-59 and ≥60 years versus ≤40 years), while there were no clear trends in severe complications (Clavien-Dindo grade 3a-5) (aOR: 0.81, P = 0.481, and aOR: 0.78, P = 0.486, respectively) or comprehensive complication index (beta coefficient: -1.49, P = 0.046, and -1.66, P = 0.083, respectively).
CONCLUSION: Age is associated with significant differences in presentation in patients undergoing adrenalectomy for pheochromocytoma, but does not have a clear association with postoperative complications. Pheochromocytoma postoperative morbidity is more likely affected by 'high-risk' disease rather than exclusively by age.