Scandinavian journal of primary health care · 1994
Vaginal application of lactobacilli in the prophylaxis of recurrent lower urinary tract infection in women.
Клиническое исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Baerheim A, Larsen E, Digranes A
Аннотация
OBJECTIVE: To examine whether vaginal application of Lactobacillus casei v. rhamnosus reduces the reinfection rate in cystitis-prone women.
DESIGN: A controlled, randomized, double-blind clinical trial.
SETTING: Division for General Practice, University of Bergen, Norway.
INTERVENTION: Vaginal application of lactobacilli twice weekly.
SUBJECTS: 47 women, aged 18-50 years, reporting three or more episodes of distal urinary symptoms during the previous 12 months, of which at least one episode had been medically verified as a lower UTI.
MAIN OUTCOME MEASURE: The incidence rate of lower UTI during 6 months' follow-up.
RESULTS: No difference in infection rate between the two groups; the incidence rate ratio between the treatment group and the placebo group was 1.41 (95% confidence interval 0.88-1.98). Lactobacilli were not found more frequently periurethrally in the treatment group than in the control group.
CONCLUSION: It is still uncertain whether vaginal application of lactobacilli reduces the infection rate in cystitis-prone women.
DESIGN: A controlled, randomized, double-blind clinical trial.
SETTING: Division for General Practice, University of Bergen, Norway.
INTERVENTION: Vaginal application of lactobacilli twice weekly.
SUBJECTS: 47 women, aged 18-50 years, reporting three or more episodes of distal urinary symptoms during the previous 12 months, of which at least one episode had been medically verified as a lower UTI.
MAIN OUTCOME MEASURE: The incidence rate of lower UTI during 6 months' follow-up.
RESULTS: No difference in infection rate between the two groups; the incidence rate ratio between the treatment group and the placebo group was 1.41 (95% confidence interval 0.88-1.98). Lactobacilli were not found more frequently periurethrally in the treatment group than in the control group.
CONCLUSION: It is still uncertain whether vaginal application of lactobacilli reduces the infection rate in cystitis-prone women.