Human psychopharmacology · 2026
Verbal and Visuospatial Working Memory Performance During the CO2 Challenge Model of Anxiety.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Dunger Warren, Edwards Marc, Board Alex, Garner Matthew
Аннотация
OBJECTIVE: Anxiety influences working memory performance, but the effects on clinical neuropsychological assessments of working memory are not well known.
METHODS: We examined the effect of anxiety, induced using the 7.5% carbon dioxide model of anxiety on standardized clinical neuropsychological tests of working memory and executive function in a single-blind, placebo-controlled, randomized, crossover within-subjects design.
RESULTS: The CO2-challenge reduced spatial working memory performance and verbal working memory performance accuracy when task demands were high. The CO2-challenge increased effort and reduced processing efficiency across all verbal and spatial working memory tasks.
CONCLUSIONS: The CO2-challenge resulted in significant reductions in working memory performance and processing efficiency. These results encourage the routine assessment of anxiety when administering and interpreting neuropsychological measures of working memory function in clinical practice.
METHODS: We examined the effect of anxiety, induced using the 7.5% carbon dioxide model of anxiety on standardized clinical neuropsychological tests of working memory and executive function in a single-blind, placebo-controlled, randomized, crossover within-subjects design.
RESULTS: The CO2-challenge reduced spatial working memory performance and verbal working memory performance accuracy when task demands were high. The CO2-challenge increased effort and reduced processing efficiency across all verbal and spatial working memory tasks.
CONCLUSIONS: The CO2-challenge resulted in significant reductions in working memory performance and processing efficiency. These results encourage the routine assessment of anxiety when administering and interpreting neuropsychological measures of working memory function in clinical practice.