Wei sheng yan jiu = Journal of hygiene research · 2011
[Research of chromosome aberration in Chinese hamster lung fibroblast induced by VEGF siRNA].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Jing Chunxia, Zhang Huan, Yang Guang, Wu Chipeng, He Lin
Аннотация
OBJECTIVE: To explore the effects of VEGF siRNA on chromosome aberration in Chinese hamster lung fibroblasts (CHL).
METHODS: The chromosome aberrations were observed after CHL were transfected with VEGF siRNA for 24 hours and 48h.
RESULTS: There were a questionable positive in 100nmol/L VEGF siRNA after VEGF siRNA were transfected for 24h and the chromosome aberration rate was 6 percentages. Both 50nmol/L VEGF siRNA and 100nmol/L VEGF siRNA caused the questionable positive after VEGF siRNAs were transfected for 48h, and the chromosome aberration rates was 6 percentages and 10 percentages separately. There were no the chromosome aberration in 25nmol/L VEGF siRNA. The types of chromosomal aberration induced by VEGF siRNAs included break, Dicentric grain, polyploid, gap, and three trajectories.
CONCLUSION: 100nmol/L VEGF siRNA might cause CHL chromosome aberration.
METHODS: The chromosome aberrations were observed after CHL were transfected with VEGF siRNA for 24 hours and 48h.
RESULTS: There were a questionable positive in 100nmol/L VEGF siRNA after VEGF siRNA were transfected for 24h and the chromosome aberration rate was 6 percentages. Both 50nmol/L VEGF siRNA and 100nmol/L VEGF siRNA caused the questionable positive after VEGF siRNAs were transfected for 48h, and the chromosome aberration rates was 6 percentages and 10 percentages separately. There were no the chromosome aberration in 25nmol/L VEGF siRNA. The types of chromosomal aberration induced by VEGF siRNAs included break, Dicentric grain, polyploid, gap, and three trajectories.
CONCLUSION: 100nmol/L VEGF siRNA might cause CHL chromosome aberration.