Tumor-localizing fluorescent diagnostic agents without phototoxicity.

In order to develop tumor-localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT-DO1 and has a molecular formula of m-phthalyl-([13,17-bispropanoic acid-3-ethenyl-8-formylethylidene-7-hydroxy-2,7,12,18-tetramethyl- porphyrinate]-manganese (III))-[3'-ethenyl-8'-formylethylidene-7'-hydroxy-2',7',12',18'-te tramethyl- porphine-13',17'-bispropanoyl aspartic acid]-bishydrazone.