Nirmatrelvir methyl tert-butyl ether solvate.

The structure of nirmatrelvir MTBE solvate, C23H32F3N5O4·C5H12O, at 150 K has monoclinic (P21) symmetry. The asymmetric unit contains one nirmatrelvir mol-ecule and one methyl tert-butyl ether solvent mol-ecule. The extended structure consists of N-H⋯O hydrogen bonds that create create [010] chains. Crystals of the title compound were grown from various methyl tert-butyl ether-methanol solvent mixtures, with crystal morphology dependent upon the mixture ratio.