A case of manic state in which lactation occurred after Li2CO3 administration.

Li2CO3 alone was administered to a 21-year-old female, who was in a manic state. As a consequence, lactation occurred on about the 50th day after Li2CO3 administration started, and the volume of lactation changed in parallel with the serum Li2CO3 level. The basal plasma PRL concentration and the responses to TRH (500 micrograms) were elevated during Li2CO3 administration. However, both of them returned to within the normal range after the suspension of Li2CO3 administration. From the above-mentioned findings, it is suggested that lactation is closely related to the Li2CO3 administration.