Frontiers in physiology · 2024
Characterization of the craniofacial abnormalities of the homozygous G608G progeria mouse model.
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Beeram Indeevar, Cubria Maria Belen, Kamalapathy Pramod, Yeritsyan Diana, Dubose Amanda J, Razavi Ahmad Hedayatzadeh, Nafisi Nazanin, Erdos Michael R, Snyder Brian D, Cabral Wayne A, Collins Francis S, Nazarian Ara
Аннотация
INTRODUCTION: Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by premature aging, impacting multiple organ systems, including cardiovascular, musculoskeletal, and integumentary. Significant abnormalities in a transgenic mouse model (homozygous G608G mutation), specifically targeting the development of skull and facial bone indices through high-resolution CT scanning and cephalometric analysis.
METHODS: Key measurements include bone thickness, skull volume, and cranial suture integrity. Bone volume increased significantly in HGPS mice by 8 months of age compared to wildtype mice.
RESULTS: Cortical thickness showed a trend toward increased values in HGPS mice. Cranial metrics revealed distinct differences.
DISCUSSION: HGPS mice exhibited smaller internasal width, interzygomatic distance, and palatine length compared to WT mice over time.
METHODS: Key measurements include bone thickness, skull volume, and cranial suture integrity. Bone volume increased significantly in HGPS mice by 8 months of age compared to wildtype mice.
RESULTS: Cortical thickness showed a trend toward increased values in HGPS mice. Cranial metrics revealed distinct differences.
DISCUSSION: HGPS mice exhibited smaller internasal width, interzygomatic distance, and palatine length compared to WT mice over time.