Fertility and sterility · 2001
Karyotype of the abortus in recurrent miscarriage.
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Carp H, Toder V, Aviram A, Daniely M, Mashiach S, Barkai G
Аннотация
OBJECTIVE: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage.
DESIGN: Retrospective analysis.
SETTING: Tertiary referral unit in university hospital.
PATIENT(S): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
INTERVENTION(S): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
MAIN OUTCOME MEASURE(S): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
RESULT(S): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
CONCLUSION(S): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.
DESIGN: Retrospective analysis.
SETTING: Tertiary referral unit in university hospital.
PATIENT(S): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
INTERVENTION(S): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
MAIN OUTCOME MEASURE(S): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
RESULT(S): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
CONCLUSION(S): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.