Synthesis of a CeO2-Au nanozyme-doped MoS2/MWCNT composite network for the electrochemical detection of tanshinone IIA.

Tanshinone IIA is a bioactive component of diterpenoid tanshinones and has broad application potential in the treatment of cardiovascular and cerebrovascular conditions. In this study, we aimed to fabricate an electrochemical sensor for detecting tanshinone IIA. For this purpose, we developed a novel composite electrode material, CeO2-Au/MoS2/MWCNTs. The CeO2-Au nanozyme was synthesized using a hydrothermal method and subsequently integrated onto a MoS2/MWCNT nanostructure for the detection of tanshinone IIA. This electrode material demonstrates superior electron transfer efficiency and catalytic performance, facilitating the fast and accurate detection of tanshinone IIA. Transmission electron microscopy and X-ray diffraction were utilized to identify and characterize its nanostructure and elemental composition. Under optimized conditions, an enzyme-free detection system for tanshinone IIA was developed, exhibiting a broad linear range and a low detection limit of 15 nM. Furthermore, the results demonstrated that the sensor exhibited good stability and reliable accuracy in detecting tanshinone IIA in natural samples. This work introduces a highly efficient sensor for detecting diterpenoid tanshinones and contributes to the broader application of nanozyme materials in electrochemical sensing.