[Antagonism of vitamin E on lipid peroxidation in testis of male rats with carbon disulfide].

OBJECTIVE

To study the antagonistic joint action of vitamin E (VE) lipid peroxidation of testis in the male rats with carbon disulfide (CS2).

METHODS

36 wistar male rats were randomly dicided into six groups. It took 10-week for the rats to breath CS2 in different concentrations (0, 50, 250 and 1250 mg/m3), respectively, CS2 (1250 mg/m3) with VE (250 mg/kg diet) and VE (250 mg/kg diet) group. After 10-week treatment, rats were killed and the following parameters of lipid peroxidation in testis were determined:SOD, MDA, GST, GSH, GSH-px, NO, NOS and iNOS.

RESULTS

Compare with the control group, SOD, GST, GSH-px, NOS and iNOS activity were decreased (P < 0.05 or P < 0.01), GSH, NO content decreased also, MDA content was increased (P < 0.01). After the antioxidant VE treatmented, the parameters were significantly increased (the amount of MDA was decreased).

CONCLUSION

The antioxidant VE significantly protects against on lipid peroxidation in testes of male rats with CS2.