Clinical and experimental dental research · 2026
Effect of Porphyromonas gingivalis Infection on PGC-1α in Skeletal Muscle After Endurance Training In Vivo.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hayashi Kairi, Takeuchi Yasuo, Kobayashi Hiroaki, Tanabe Gen, Churei Hiroshi, Ueno Toshiaki, Fueki Kenji
Аннотация
OBJECTIVES: It is well known that Porphyromonas gingivalis, a major pathogen in periodontitis, causes systemic diseases. This study investigated the expression of PGC-1α (the most important factor in muscle mitochondria synthesis) following endurance training to clarify the relationship between P. gingivalis infection and muscle endurance capacity.
MATERIALS AND METHODS: Twenty 8-week-old Wistar rats were randomly divided into two groups. One group was intraperitoneally administered sonicated P. gingivalis (P. g-group), and the other group was administered saline (Control-group). Three weeks after administration, gastrocnemius muscles and blood from both groups were collected 24 h after treadmill exercise. The expressions of PGC-1α and TNF-α in gastrocnemius muscle were measured, along with serum antibody titers for IgG, in response to P. gingivalis.
RESULTS: Serum IgG antibody titers and TNF-α expression in skeletal muscle were significantly higher in the P. g-group than in the Control-group. PGC-1α expression was significantly lower in the P. g-group than in the Control-group. A correlation was observed between PGC-1α and TNF-α expression.
CONCLUSION: Our result suggests that the increase in endurance following training may be suppressed by P. gingivalis infection.
MATERIALS AND METHODS: Twenty 8-week-old Wistar rats were randomly divided into two groups. One group was intraperitoneally administered sonicated P. gingivalis (P. g-group), and the other group was administered saline (Control-group). Three weeks after administration, gastrocnemius muscles and blood from both groups were collected 24 h after treadmill exercise. The expressions of PGC-1α and TNF-α in gastrocnemius muscle were measured, along with serum antibody titers for IgG, in response to P. gingivalis.
RESULTS: Serum IgG antibody titers and TNF-α expression in skeletal muscle were significantly higher in the P. g-group than in the Control-group. PGC-1α expression was significantly lower in the P. g-group than in the Control-group. A correlation was observed between PGC-1α and TNF-α expression.
CONCLUSION: Our result suggests that the increase in endurance following training may be suppressed by P. gingivalis infection.