[Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context].

Metabolic syndrome (MetS) is a multifactorial condition involving environmental factors, lifestyle behaviors, and genetic variants. The objective of this review was to analyze and compare the available evidence on genetic susceptibility to MetS in the Mexican population and in other regions of the world, in order to identify convergences and population-specific features. A narrative review of the scientific literature published between 2020 and 2025 was conducted using international databases. The methodological quality and scientific relevance of the studies were assessed using criteria adapted from the Q-Genie instrument. The results show that genetic variants involved in glucose and lipid metabolism, as well as in blood pressure regulation, are associated with MetS across diverse populations. However, relevant differences were identified in the frequency and phenotypic effects of these variants between the Mexican population and other regions worldwide. In conclusion, the evidence suggests that genetic susceptibility to MetS exhibits a population-specific component in Mexico. In this context, further investigation of genetic variants associated with MetS is warranted to contribute to the strengthening of preventive strategies aimed at reducing the burden of MetS in the Mexican population.