Fertility and sterility · 2010
Ex-vivo oocyte retrieval for fertility preservation.
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Fatemi Human M, Kyrou Dimitra, Al-Azemi Majedah, Stoop Dominique, De Sutter Philippe, Bourgain Claire, Devroey Paul
Аннотация
OBJECTIVE: To report a novel fertility preservation strategy in a woman with recurrent serous borderline ovarian tumor in the conserved ovary involving ex-vivo retrieval of in vivo matured oocytes and subsequent embryo cryopreservation.
DESIGN: Case report.
SETTING: Tertiary infertility care unit.
PATIENT(S): A 27-year-old woman presented for follow-up visit with a history of borderline serous adenocarcinoma treated conservatively with left oophorectomy and fertility-sparing laparoscopic staging. Ultrasound scan revealed a recurrent disease in the right ovary.
INTERVENTION(S): Ex-vivo retrieval of mature oocytes after ovarian stimulation.
MAIN OUTCOME MEASURE(S): Fertility preservation.
RESULT(S): The patient underwent ovarian stimulation followed by a laparotomy and oophorectomy on the day of oocyte retrieval. A puncture of the follicles was performed in the operating theatre with a maximum ischemia time of 14 minutes. Eleven mature oocytes were aspirating, resulting in seven zygotes for cryopreservation.
CONCLUSION(S): Mature oocytes can be successfully retrieved ex-vivo from the oophorectomy specimen after a controlled ovarian hyperstimulation (COH) protocol. This method provides a possible strategy for fertility preservation in patients with recurrent ovarian cancer without the risk of cancer cells spillage associated with the standard transvaginal oocyte retrieval.
DESIGN: Case report.
SETTING: Tertiary infertility care unit.
PATIENT(S): A 27-year-old woman presented for follow-up visit with a history of borderline serous adenocarcinoma treated conservatively with left oophorectomy and fertility-sparing laparoscopic staging. Ultrasound scan revealed a recurrent disease in the right ovary.
INTERVENTION(S): Ex-vivo retrieval of mature oocytes after ovarian stimulation.
MAIN OUTCOME MEASURE(S): Fertility preservation.
RESULT(S): The patient underwent ovarian stimulation followed by a laparotomy and oophorectomy on the day of oocyte retrieval. A puncture of the follicles was performed in the operating theatre with a maximum ischemia time of 14 minutes. Eleven mature oocytes were aspirating, resulting in seven zygotes for cryopreservation.
CONCLUSION(S): Mature oocytes can be successfully retrieved ex-vivo from the oophorectomy specimen after a controlled ovarian hyperstimulation (COH) protocol. This method provides a possible strategy for fertility preservation in patients with recurrent ovarian cancer without the risk of cancer cells spillage associated with the standard transvaginal oocyte retrieval.