Comparison of perinatal outcomes and pregnancy complications between fresh embryo transfer and frozen embryo transfer in singleton pregnant women.

OBJECTIVES

To compare perinatal outcomes and the incidence of pregnancy complications between fresh embryo transfer and frozen embryo transfer in singleton pregnant women.

METHODS

The clinical data of 3161 in vitro fertilization-embryo transfer cycles conducted in Center for Reproductive Medicine of the Third Affiliated Hospital of Sun Yat-sen University from October 2015 to May 2021 were retrospectively analyzed, among which 1009 cases were fresh embryo transfer (fresh embryo group) and 2152 cases were frozen embryo transfer (frozen embryo group). The baseline characteristics were compared between two groups, and logistic regression was used to analyze the effect of fresh embryo transfer and frozen embryo transfer on pregnancy outcome and complications.

RESULTS

Compared with the fresh embryo group, the frozen embryo group had an increased gestational age (P<0.01), increased birth weight (P<0.01), higher cesarean section rate (65.1% vs. 50.7%, AOR=1.791, 95%CI: 1.421-2.256, P<0.01), higher risk of large for gestational age infant (12.7% vs. 9.4%, AOR=1.487, 95%CI: 1.072-2.064, P<0.05) and macrosomia (5.4% vs. 3.2%, AOR=2.126, 95%CI: 1.262-3.582, P<0.01). The incidences of early abortion (18.5% vs. 16.2%, AOR=1.377, 95%CI: 1.099-1.725, P<0.01) and gestational hypertension (3.1% vs. 1.9%, AOR=1.862, 95%CI: 1.055-3.285, P<0.05) in the frozen embryo group were significantly higher than those in the fresh embryo group. Stratified analyses by stage of embryo transfer showed that during blastocyst transfer, the gestational weeks of delivery, birth weight and risk of cesarean section in frozen embryo group were significantly higher than those in fresh embryo group. During cleavage stage embryo transfer, frozen embryo transfer was associated with a higher risk of cesarean section, macrosomia, miscarriage and early miscarriage, and the birth weight of newborns was also significantly increased.

CONCLUSIONS

Compared with fresh embryo transfer, frozen embryo transfer is associated with a higher risk of abortion, early abortion, large for gestational age infant, macrosomia, cesarean section, and pregnancy induced hypertension. The birth weight of newborns after frozen embryo transfer is also significantly increased.