[Interleukin-1 activity regulators in acute decompensated heart failure: dependence on obesity degree].

AIM: To assess the circulating levels of IL-1 and its activity regulators, IL-1Ra and IL-1R2, in patients with acute decompensated heart failure (ADHF) depending on body mass index (BMI).

MATERIALS AND

METHODS

The study included 159 patients hospitalized for ADHF. Depending on the BMI, the patients were assigned to 5 groups. The first group included 30 patients with healthy weight (BMI<25 kg/m2), the second - 50 overweight patients (25≤BMI<30 kg/m2), the third - 38 patients with class I obesity (30≤BMI<35 kg/m2), the fourth - 28 patients with class II obesity (35≤BMI<40 kg/m2), the fifth group - 13 patients with class III obesity (BMI≥40 kg/m2).

RESULTS

With increasing BMI, IL-1 levels increased, while IL-1R2 levels, on the contrary, decreased, but no statistically significant differences were found. IL-1Ra concentrations changed ambiguously and had U-shaped dependence. IL-1Ra levels were lower in overweight patients than in normal weight and obese groups. At the same time, the increase in obesity was accompanied by higher IL-1Ra levels. The highest IL-1Ra value was observed at a BMI≥40 kg/m2.

CONCLUSION

In ADHF an increase in obesity is accompanied by an increase in the inhibition of IL-1 activity, which may be one of the mechanisms by which adipose tissue exerts a protective effect.