The Veterinary record · 2025
Effects of meloxicam and flunixin meglumine on oxidative stress and pregnancy factors in Awassi sheep.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Akkuş Tuğra, Yaprakcı Ömer, Günal İsmail, Ekici Mehmet, Emre Birten, Korkmaz Ömer, Zonturlu Abuzer K
Аннотация
BACKGROUND: This study aimed to evaluate the effects of administering flunixin meglumine (FM) and meloxicam (M) on specific days post-mating on progesterone (P4), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), pregnancy-specific protein B (PSPB), pregnancy-associated glycoprotein (PAG) concentrations and fertility parameters in Awassi sheep.
METHODS: Seventy-five Awassi sheep were divided into three groups of 25: control, M and FM. On days 9 and 10 post-mating, the control group received saline, the M group received 0.5 mg/kg M and the FM group received 2.2 mg/kg FM. Blood samples were collected on days 8, 9, 10, 11, 12 and 17 post-mating.
RESULTS: Statistically significant time-dependent differences in P4, TAS, TOS, OSI, PSPB and PAG concentrations were found between the groups (p < 0.001). TAS was highest in the M group and lowest in the control group (p < 0.001). TOS was higher in the control group and lower in the M group (p < 0.001). PSPB and PAG were highest in the control group and lowest in the M group (p < 0.05).
LIMITATION: Further studies with larger sample sizes are needed to confirm the findings.
CONCLUSION: FM and M significantly affected oxidative stress parameters and early pregnancy factors but not fertility parameters.
METHODS: Seventy-five Awassi sheep were divided into three groups of 25: control, M and FM. On days 9 and 10 post-mating, the control group received saline, the M group received 0.5 mg/kg M and the FM group received 2.2 mg/kg FM. Blood samples were collected on days 8, 9, 10, 11, 12 and 17 post-mating.
RESULTS: Statistically significant time-dependent differences in P4, TAS, TOS, OSI, PSPB and PAG concentrations were found between the groups (p < 0.001). TAS was highest in the M group and lowest in the control group (p < 0.001). TOS was higher in the control group and lower in the M group (p < 0.001). PSPB and PAG were highest in the control group and lowest in the M group (p < 0.05).
LIMITATION: Further studies with larger sample sizes are needed to confirm the findings.
CONCLUSION: FM and M significantly affected oxidative stress parameters and early pregnancy factors but not fertility parameters.