Editorial: Accelerating antibiotic development from natural products: tackling antimicrobial resistance (AMR).

Accelerating antibiotic development from natural products. Natural products with antimicrobial activity can act through multiple mechanisms to overcome antibiotic resistance. These include directly inhibiting bacterial growth, reversing resistance by blocking efflux pumps and disrupting biofilms, and strengthening host defenses. Together, these strategies help restore antibiotic effectiveness, overcome resistance, and support more sustainable approaches to treating infections. Image created by Dr Ankita Nag in BioRender. (https://BioRender.com/6c0p6qp), licensed under CC BY 4.0.Infographic illustrating key natural sources of antimicrobial compounds, such as plants, microbes, fungi, endophytes, and marine life, alongside antimicrobial strategies including inhibiting bacterial survival, enhancing host defense, and reversing resistance, with a diagram detailing bacterial drug resistance mechanisms like drug modification, target polymorphism, impermeability, and efflux.