[Proteomics and biomarkers for detection of preterm labor: a systematic review].

OBJECTIVE

To review the published articles about identification of biomarkers of spontaneous preterm birth using a proteomic approach and to create a list of potential biomarkers.

DESIGN

Systematic review of literature.

SETTING

Department of Obstetrics and Gynecology, Medical Faculty Charles University Hradec Kralove.

METHODS

The following databases were accessed in search of relevant citation: MEDLINE, SCOPUS and PubMed. Totally 101 references were identified and relevant 37 abstracts were screened. As appropriated were pointed 16 studies. Finally, the data were extracted from five articles.

CONCLUSION

The implementation of high-throughput technologies is necessary in the field of spontaneous preterm birth research. A compelling option is the use of proteomics in the area spontaneous preterm birth biomarkers identification in amniotic fluid, maternal serum/plasma, cervical-vaginal fluid and placental tissue. The data was extracted from published articles and a list of 72 proteins was created.