Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2010
[Regulations of Hedgehog signaling pathway on mesenchymal stem cells].
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Cai Jiaqin, Deng Li
Аннотация
OBJECTIVE: To summarize the regulations of Hedgehog signaling pathway on the proliferation and multi-differentiation of mesenchymal stem cells (MSCs).
METHODS: The related literature in recent years concerning the regulations of Hedgehog signaling pathway on the biological characteristics of MSCs was reviewed and analyzed.
RESULTS: Hedgehog signaling pathway promoted the proliferation of MSCs, and played a major role in the induction of osteogenic and chondrogenic differentiations, but it inhibited the adipocytic differentiation.
CONCLUSION: The regulations of Hedgehog signaling pathway in MSCs multi-differentiation and proliferation could be used as the new therapeutic targets of tissue ischemia, osteoporosis, achondroplasia, obesity, and so on.
METHODS: The related literature in recent years concerning the regulations of Hedgehog signaling pathway on the biological characteristics of MSCs was reviewed and analyzed.
RESULTS: Hedgehog signaling pathway promoted the proliferation of MSCs, and played a major role in the induction of osteogenic and chondrogenic differentiations, but it inhibited the adipocytic differentiation.
CONCLUSION: The regulations of Hedgehog signaling pathway in MSCs multi-differentiation and proliferation could be used as the new therapeutic targets of tissue ischemia, osteoporosis, achondroplasia, obesity, and so on.