[Regulations of Hedgehog signaling pathway on mesenchymal stem cells].

OBJECTIVE

To summarize the regulations of Hedgehog signaling pathway on the proliferation and multi-differentiation of mesenchymal stem cells (MSCs).

METHODS

The related literature in recent years concerning the regulations of Hedgehog signaling pathway on the biological characteristics of MSCs was reviewed and analyzed.

RESULTS

Hedgehog signaling pathway promoted the proliferation of MSCs, and played a major role in the induction of osteogenic and chondrogenic differentiations, but it inhibited the adipocytic differentiation.

CONCLUSION

The regulations of Hedgehog signaling pathway in MSCs multi-differentiation and proliferation could be used as the new therapeutic targets of tissue ischemia, osteoporosis, achondroplasia, obesity, and so on.