Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population.

INTRODUCTION

This study aimed to compare Fetal Medicine Foundation (FMF), Indonesian Maternal and Children Health Handbook (MCH-HB), and Indonesian Prenatal Institute (IPI) models for predicting PE.

MATERIALS/SUBJECTS AND

METHODS

Maternal risk factors, biophysical, and biochemical markers were recorded from women screened for PE at 11-14 gestational weeks. The receiving operator curve (ROC) analysis was used to compare the detection rate (DR) among prediction models.

RESULTS

For all PE at a 10% false-positive rate (FPR), FMF had a DR 62.9%; MCH-HB had a DR 50.0%; IPI had a DR 66.9%. For early-onset PE, at 10% FPR FMF had a DR 80.3%; MCH-HB had a DR 71.4%; IPI had a DR 81.5%. For preterm PE at 10% FPR, FMF had a DR 70.2%; MCH-HB had a DR 38.5%; IPI had a DR 66.9%.

DISCUSSION: IPI algorithm is comparable to FMF and outperforms MCH-HB algorithm for all, early-onset, and preterm PE screening.