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DOI 10.1038/nature22400

Медицинская библиотека · Nature · 2017

Genomic epidemiology reveals multiple introductions of Zika virus into the United States.

Grubaugh Nathan D, Ladner Jason T, Kraemer Moritz U G, Dudas Gytis, Tan Amanda L, Gangavarapu Karthik, Wiley Michael R, White Stephen, Thézé Julien, Magnani Diogo M, Prieto Karla, Reyes Daniel, Bingham Andrea M, Paul Lauren M, Robles-Sikisaka Refugio, Oliveira Glenn, Pronty Darryl, Barcellona Carolyn M, Metsky Hayden C, Baniecki Mary Lynn, Barnes Kayla G, Chak Bridget, Freije Catherine A, Gladden-Young Adrianne, Gnirke Andreas, Luo Cynthia, MacInnis Bronwyn, Matranga Christian B, Park Daniel J, Qu James, Schaffner Stephen F, Tomkins-Tinch Christopher, West Kendra L, Winnicki Sarah M, Wohl Shirlee, Yozwiak Nathan L, Quick Joshua, Fauver Joseph R, Khan Kamran, Brent Shannon E, Reiner Robert C, Lichtenberger Paola N, Ricciardi Michael J, Bailey Varian K, Watkins David I, Cone Marshall R, Kopp Edgar W, Hogan Kelly N, Cannons Andrew C, Jean Reynald, Monaghan Andrew J, Garry Robert F, Loman Nicholas J, Faria Nuno R, Porcelli Mario C, Vasquez Chalmers, Nagle Elyse R, Cummings Derek A T, Stanek Danielle, Rambaut Andrew, Sanchez-Lockhart Mariano, Sabeti Pardis C, Gillis Leah D, Michael Scott F, Bedford Trevor, Pybus Oliver G, Isern Sharon, Palacios Gustavo, Andersen Kristian G

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПеревод в очереди

Аннотация

Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.

Для цитирования: Grubaugh Nathan D, Ladner Jason T, Kraemer Moritz U G, Dudas Gytis, Tan Amanda L, Gangavarapu Karthik, Wiley Michael R, White Stephen, Thézé Julien, Magnani Diogo M, Prieto Karla, Reyes Daniel, Bingham Andrea M, Paul Lauren M, Robles-Sikisaka Refugio, Oliveira Glenn, Pronty Darryl, Barcellona Carolyn M, Metsky Hayden C, Baniecki Mary Lynn, Barnes Kayla G, Chak Bridget, Freije Catherine A, Gladden-Young Adrianne, Gnirke Andreas, Luo Cynthia, MacInnis Bronwyn, Matranga Christian B, Park Daniel J, Qu James, Schaffner Stephen F, Tomkins-Tinch Christopher, West Kendra L, Winnicki Sarah M, Wohl Shirlee, Yozwiak Nathan L, Quick Joshua, Fauver Joseph R, Khan Kamran, Brent Shannon E, Reiner Robert C, Lichtenberger Paola N, Ricciardi Michael J, Bailey Varian K, Watkins David I, Cone Marshall R, Kopp Edgar W, Hogan Kelly N, Cannons Andrew C, Jean Reynald, Monaghan Andrew J, Garry Robert F, Loman Nicholas J, Faria Nuno R, Porcelli Mario C, Vasquez Chalmers, Nagle Elyse R, Cummings Derek A T, Stanek Danielle, Rambaut Andrew, Sanchez-Lockhart Mariano, Sabeti Pardis C, Gillis Leah D, Michael Scott F, Bedford Trevor, Pybus Oliver G, Isern Sharon, Palacios Gustavo, Andersen Kristian G. Genomic epidemiology reveals multiple introductions of Zika virus into the United States.. Nature. 2017. DOI: 10.1038/nature22400.

Предметные рубрики MeSH

AedesAnimalsCaribbean RegionDisease OutbreaksFemaleFloridaGenome, ViralHumansIncidenceMolecular EpidemiologyMosquito VectorsZika VirusZika Virus Infection
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