International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Identifying rate-limiting steps in the antimicrobial workflow for community-onset sepsis.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Song Myung Jin, Won Seunghyun, Kim Min Chul, Jung Seyoung, Ko Ryoung-Eun, Park Sunghoon, Suh Gee Young, Lee Yeon Joo, Korean Sepsis Alliance (KSA)
Аннотация
OBJECTIVES: To characterize time intervals preceding antimicrobial administration in community-onset sepsis and identify rate-limiting steps.
METHODS: In this multicenter prospective observational study of patients with community-onset sepsis in South Korea (June 2020-December 2023), the antimicrobial workflow was defined by five time points: time zero, blood culture prescription and collection, and antimicrobial prescription and administration. Patients were categorized into three groups by step sequence, and four key intervals were analyzed.
RESULTS: Among 3623 patients (mean age 74.3 ± 13.0 years; 56.6% male), 1838 (50.7%) were assigned to Group A (antimicrobials and cultures prescribed before culture collection), 1517 (41.9%) to Group B (cultures obtained before antimicrobial prescription), and 268 (7.4%) to Group C (antimicrobials given before culture collection). Median time from time zero to administration was shortest in Group C (63.5 min), then Group A (87.0 min) and Group B (115.0 min). The rate-limiting step differed by group: prescription-to-administration in Group A, time-zero-to-prescription in Group B, and culture prescription-to-collection in Group C. Septic shock was associated with shorter intervals overall, except prescription-to-administration, which was unchanged.
CONCLUSION: Rate-limiting steps in antimicrobial delivery differ by clinical workflow. Early concurrent prescription of antimicrobials and blood cultures was associated with shorter time to antimicrobial administration.
METHODS: In this multicenter prospective observational study of patients with community-onset sepsis in South Korea (June 2020-December 2023), the antimicrobial workflow was defined by five time points: time zero, blood culture prescription and collection, and antimicrobial prescription and administration. Patients were categorized into three groups by step sequence, and four key intervals were analyzed.
RESULTS: Among 3623 patients (mean age 74.3 ± 13.0 years; 56.6% male), 1838 (50.7%) were assigned to Group A (antimicrobials and cultures prescribed before culture collection), 1517 (41.9%) to Group B (cultures obtained before antimicrobial prescription), and 268 (7.4%) to Group C (antimicrobials given before culture collection). Median time from time zero to administration was shortest in Group C (63.5 min), then Group A (87.0 min) and Group B (115.0 min). The rate-limiting step differed by group: prescription-to-administration in Group A, time-zero-to-prescription in Group B, and culture prescription-to-collection in Group C. Septic shock was associated with shorter intervals overall, except prescription-to-administration, which was unchanged.
CONCLUSION: Rate-limiting steps in antimicrobial delivery differ by clinical workflow. Early concurrent prescription of antimicrobials and blood cultures was associated with shorter time to antimicrobial administration.