Comparison of the biocidal efficacy of sodium dichloro-iso-cyanurate, double antibiotic pastes and calcium hydroxide as intra-canal medicaments for regenerative endodontic therapy: an ex-vivo study.

PURPOSE: This study aimed to determine the antibacterial efficacy of sodium dichloro-iso-cyanurate (NaDCC) compared to double antibiotic paste (DAP) and calcium hydroxide (CH) against Enterococcus faecalis (E. faecalis).

METHODS

The study utilized a sample of forty-four human single-rooted teeth, which were decoronated and chemo-mechanically prepared. E. faecalis was then inoculated into the teeth for four weeks. The samples were randomly divided into four groups, each receiving a different intracanal medicament: DAP ([Formula: see text]), NaDCC ([Formula: see text]), CH ([Formula: see text]), and a control group treated with sterile water ([Formula: see text]). After a contact time of 28 days, a sample was taken from each root canal with a paper point. The number of colony-forming units was then calculated, and data analysis was performed using Kruskal Wallis and Mann-Whitney tests.

RESULTS

All the medicaments had a significantly higher antibacterial effect than the control group ([Formula: see text]). DAP showed a significantly higher antibacterial effect than NaDCC ([Formula: see text]) and CH ([Formula: see text]). NaDCC showed a significantly higher antibacterial effect than CH ([Formula: see text]).

CONCLUSION

The study's results indicate that DAP is the most effective medicament against E. faecalis. However, the study also revealed that NaDCC, a relatively novel substance in endodontics, demonstrated a higher antibacterial efficacy than CH. This suggests that NaDCC could be a promising addition to the range of medicaments used in regenerative procedures.