Association of C-Reactive Protein-Triglyceride Glucose Index With Chronic Kidney Disease and Reduction of Renal Function.

OBJECTIVES

The C-reactive protein-triglyceride glucose index (CTI) is a novel biomarker integrating insulin resistance and systemic inflammation, both of which are implicated in the pathogenesis of chronic kidney disease (CKD). This study aimed to investigate the association of CTI with CKD and the reduction of renal function.

METHODS

This study used China Health and Retirement Longitudinal Study data from 2011 to 2015. The 2011 and 2015 cross-sectional studies included 5,242 and 8,056 participants aged ≥45 years, respectively. A total of 3,435 eligible subjects participated in the longitudinal cohort study. Logistic regression, linear regression, and restricted cubic splines were used to assess the association of CTI with CKD, estimated glomerular filtration rate, and reduction of renal function, with subgroup and interaction analyses performed.

RESULTS

The study demonstrated a positive association between CTI and CKD in both 2011 (odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.21, 1.41; P < .001) and 2015 (OR = 1.44, 95% CI: 1.34, 1.56; P < .001) cross-sectional studies, with inverse associations observed with estimated glomerular filtration rate. In the longitudinal cohort study, there was a positive association of CTI with the incidence of new-onset CKD (OR = 1.26, 95% CI: 1.08, 1.47; P = .003) and reduction of renal function with CKD (OR = 1.71, 95% CI: 1.31, 2.25; P < .001).

CONCLUSION

CTI levels are significantly associated with CKD and the reduction of renal function, indicating its potential as a clinical biomarker for CKD risk and renal changes in middle-aged and older Chinese.