Design strategy, functional mechanism and antibacterial applications of metal-organic framework-hyaluronic acid composite.

The development of novel antimicrobial materials that combine high bactericidal efficacy, precise targeting, excellent biocompatibility, and tissue repair capabilities has emerged as a frontier and urgent demand in the field of biomedical engineering. This systematic review focuses on antimicrobial material systems constructed through the combination of metal-organic frameworks (MOFs) and hyaluronic acid (HA). It elaborates on four major design strategies: physical modification, chemical coupling, multifunctional composites, and dosage form optimization. The core functional mechanisms include targeted enrichment, pH/enzyme/photothermal trigger response, metal ion dominance, antimicrobial agent-ROS synergy, and multi-mechanism coordination. Furthermore, the extensive applications of these composites in infection wound repair, treatment of specific site infections (mucosal, ocular, and pulmonary), and antimicrobial modification of medical materials (wound dressings, tissue engineering scaffolds, medical devices) are full analyzed. Future research should focus on developing intelligent responsive multi-target synergistic systems, advancing standardized preparation and preclinical evaluation system establishment, to accelerate the translation of MOF-HA antibacterial composites from laboratory research to clinical applications, providing innovative material solutions for addressing the global antimicrobial resistance crisis.