Annals of nuclear medicine · 2026
Adsorption treatment of 177Lu radioactive wastewater with 177mLu impurity: batch versus column methods.
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Sato Rintaro, Miyaji Noriaki, Hasegawa Koki, Ihara Yuma, Yabe Shigenori, Kikori Katsuyuki, Akiya Naochika, Wachi Kaito, Minami Akemi, Yamashita Kosuke, Yamao Tensho, Ohba Takashi, Miwa Kenta, Oriuchi Noboru
Аннотация
OBJECTIVE: The rapid global expansion of targeted radionuclide therapy using 177Lu-labeled radiopharmaceuticals has increased the need for effective and regulatory-compliant management of radioactive wastewater. However, long-lived impurities, such as 177mLu, which emit high-energy γ-ray emissions complicate wastewater treatment and compliance with discharge regulations. This study aimed to determine an optimal method to treat wastewater contaminated with 177Lu and 177mLu.
METHODS: Radioactive wastewater samples were collected from a storage tank in a targeted radionuclide therapy ward. The adsorption efficiency of various adsorbents, including Chelex resin, Bondesil-C18 and granular activated carbon, was assessed using both batch and column methods. Adsorption efficiency was measured as counts at 208 keV using a high-purity germanium detector.
RESULTS: The adsorption efficiency of Chelex resin and Bondesil-C18 in 100 mL of radioactive wastewater, was below 25%, whereas that of granular activated carbon was 85.9%. The adsorption efficiency of batch and column methods increased with adsorbent mass and processing time. The column method with small amounts of granular activated carbon achieved 60%-70% adsorption efficiency within ~ 7 min in a single-pass operation.
CONCLUSION: Adsorption treatment using granular activated carbon was effective for the removal of 177Lu and 177mLu from radioactive wastewater. Column method may support the management of radioactive wastewater contaminated with 177Lu and other radionuclides in clinical settings.
METHODS: Radioactive wastewater samples were collected from a storage tank in a targeted radionuclide therapy ward. The adsorption efficiency of various adsorbents, including Chelex resin, Bondesil-C18 and granular activated carbon, was assessed using both batch and column methods. Adsorption efficiency was measured as counts at 208 keV using a high-purity germanium detector.
RESULTS: The adsorption efficiency of Chelex resin and Bondesil-C18 in 100 mL of radioactive wastewater, was below 25%, whereas that of granular activated carbon was 85.9%. The adsorption efficiency of batch and column methods increased with adsorbent mass and processing time. The column method with small amounts of granular activated carbon achieved 60%-70% adsorption efficiency within ~ 7 min in a single-pass operation.
CONCLUSION: Adsorption treatment using granular activated carbon was effective for the removal of 177Lu and 177mLu from radioactive wastewater. Column method may support the management of radioactive wastewater contaminated with 177Lu and other radionuclides in clinical settings.