[Risk factors for patent ductus arteriosus in neonates].

OBJECTIVE

To identify the risk factors for patent ductus arteriosus (PDA) in neonates.

METHODS

Fifty infants with PDA and 100 infants without PDA were enrolled. Chi-square test, Student's t test and the linear correlation analysis were used to study the clinical data. Logistic regression analysis was used to investigate the independent risk factors for PDA.

RESULTS

The prevalence of PDA was negatively correlated with the gestation age (r=-0.03, P<0.05) and birth weight (r=-0.04, P<0.05). Oxygen inhalation was a protective factor for the development of PDA. Fetal distress, meconium-stained amniotic fluid, oligohydramnios, cord entanglement, 1 minute Apgar score <8, maternal infection and hypoxic-ischemic encephalopathy were the independent risk factors for the development of PDA.

CONCLUSIONS

The incidence of PDA can be reduced by preventing maternal infection, premature birth, low birth weight and hypoxia.