Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2007
Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin.
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Johnson Stuart, Schriever Christopher, Galang Minerva, Kelly Ciarán P, Gerding Dale N
Аннотация
Eight women who each experienced 4-8 episodes of Clostridium difficile-associated diarrhea were given a 2-week course of rifaximin therapy when they were asymptomatic, immediately after completing their last course of vancomycin therapy. Seven of the 8 patients experienced no further diarrhea recurrence. The patient who had a recurrence responded to a second course of rifaximin therapy, but rifaximin-resistant C. difficile was recovered after treatment. A controlled trial for treating recurrent Clostridium difficile-associated diarrhea appears to be warranted.
Предметные рубрики MeSH
AdultAge FactorsAgedClostridioides difficileDiarrheaDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationEnterocolitis, PseudomembranousFemaleFollow-Up StudiesHumansMicrobial Sensitivity TestsMiddle AgedProspective StudiesRifamycinsRifaximinRisk FactorsSecondary PreventionSeverity of Illness IndexTreatment OutcomeVancomycin