Determining the effective emetic dosage of tetrapotassium pyrophosphate (TKPP) in dogs.

The effect of TKPP on emesis was examined in adult "conditioned random source" mongrel dogs. Only dogs that exhibited emesis with CuSO4, were used. The effect of dosage and concentration of TKPP on emesis was highly significant. The effective combinations of dose and concentration were 4,800, 2,400, or 1,200 mg/head at 5, 10, or 20%. In all the tested dogs, 4,800 mg of 20% TKPP was effective inducing emesis. The mean latency of emesis in dogs was 7 min, 33 sec (95% confidence limits: 5 min, 58 sec 9 min, 7 sec).