Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials · 2004
[Studies on antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid].
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Guan Hong, Li Peifeng, Zhao Hongxia
Аннотация
OBJECTIVE: In this paper, antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid (CDCA) were studied.
METHOD: The method of strong aqua ammoniae induced cough and sulfur dioxide induced cough, the method of tracheal volume and tracheal spiral line, and phenolsulfonphthalein excretion test.
RESULTS: CDCA was able to prolong cough latent period and decrease cough rate significantly in mice resulted from strong aqua ammoniae and sulfur doxide, and inhibit contraction of whole-body or extracorpored tracheal smooth muscle in guinea pig resulted from histamine phosphate. Besides, CDCA can increase phenolsulfonphthalein excretion quantity of trachea in mice, singnificantly.
CONCLUSION: CDCA has antitussive, antiasthmatic, expectorant actions.
METHOD: The method of strong aqua ammoniae induced cough and sulfur dioxide induced cough, the method of tracheal volume and tracheal spiral line, and phenolsulfonphthalein excretion test.
RESULTS: CDCA was able to prolong cough latent period and decrease cough rate significantly in mice resulted from strong aqua ammoniae and sulfur doxide, and inhibit contraction of whole-body or extracorpored tracheal smooth muscle in guinea pig resulted from histamine phosphate. Besides, CDCA can increase phenolsulfonphthalein excretion quantity of trachea in mice, singnificantly.
CONCLUSION: CDCA has antitussive, antiasthmatic, expectorant actions.