[Studies on antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid].

OBJECTIVE

In this paper, antitussive, antiasthmatic and expectorant action of chenodeoxycholine acid (CDCA) were studied.

METHOD: The method of strong aqua ammoniae induced cough and sulfur dioxide induced cough, the method of tracheal volume and tracheal spiral line, and phenolsulfonphthalein excretion test.

RESULTS

CDCA was able to prolong cough latent period and decrease cough rate significantly in mice resulted from strong aqua ammoniae and sulfur doxide, and inhibit contraction of whole-body or extracorpored tracheal smooth muscle in guinea pig resulted from histamine phosphate. Besides, CDCA can increase phenolsulfonphthalein excretion quantity of trachea in mice, singnificantly.

CONCLUSION

CDCA has antitussive, antiasthmatic, expectorant actions.