Effect of mangosteen peel extract nanocapsule on the hematological profile and total bacterial count in broiler chickens experimentally infected with avian pathogenic Escherichia coli.

BACKGROUND

Infection by avian pathogenic Escherichia coli (APEC) in broiler chickens leads to serious health complications, including systemic inflammation, oxidative stress, and impaired immune response.

AIM: This study aimed to evaluate the effect of mangosteen peel extract nanocapsule (MPE-NC) on the hematological profiles and total bacteria in APEC-infected broilers.

METHODS

A total of 200 day old chick broiler chickens were randomly allocated to four treatments with five replicates, including T1 (negative control group), fed a basal diet without APEC infection; T2 (positive control group), fed a basal diet with APEC infection; T3: a basal diet supplemented with 0.5% MPE-NC and APEC infection; and T4: a basal diet supplemented with 1.0% MPE-NC and APEC infection. The observed parameters were the hematological blood profile and total bacterial count.

RESULTS

APEC infection significantly (p < 0.05) impaired the physiological status of broiler chickens by reducing hematological parameters and had a significant effect on total bacteria (p < 0.05). The hematological parameters were significantly improved, and the intestinal bacterial count was reduced in broiler chickens supplemented with MPE-NC compared to control treatment.

CONCLUSION

MPE-NC treatment provided optimal improvement for several tested measurements. These results indicate that MPE-NC could be used as a natural phytobiotic agent to improve physiological health and reduce the risk of bacterial infection.