Efficacy of Cosmetic Debridement and Suture With Recombinant Human EGF in Maxillofacial Trauma: A Meta-Analysis.

OBJECTIVE

To analyze and evaluate the clinical effect of cosmetic debridement and suture combined with recombinant human epidermal growth factor (rhEGF).

METHODS

A systematic review of the literature was performed by searching China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journals, China Biomedicine, PubMed, Web of Science, and Cochrane Library. RevMan 5.4.1 software was used for statistical analysis. Heterogeneity among studies was assessed using the Q test (p value). Publication bias was evaluated via funnel plots, forest plots were generated, and the combined odds ratio (OR) was calculated using a fixed-effects model or random-effects model.

RESULTS

The combined therapy showed favorable clinical efficacy [OR = 6.62, 95% confidence interval (95% CI) (3.14-13.92), p < 0.00001], shorter wound healing time [mean difference (MD) = -2.69, 95% CI (-3.10 to -2.29), p < 0.00001], and improved scar outcomes (lower Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) scores) at 6 months. Serum epidermal growth factor (EGF) levels were higher, while interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were lower in the combined therapy group (all p < 0.05).

CONCLUSION

Aesthetic debridement and suture combined with rhEGF have a good clinical effect in the treatment of maxillofacial trauma.