Ultrasmall pH-triggered cerium-based MOF nanozyme delivery system: Stable implant coating with integrated synergistic antibacterial and corrosion resistance enhancement.

The attachment of bacteria and subsequent biofilm formation is the first step toward the colonization of medical devices and implants by bacteria. Preventing the colonization of bacteria is key to averting infections. At the same time, the bacterial type Staphylococcus aureus (S.aureus) is the main pathology affecting infections on implant surfaces. The joint effects of natural selection and antibiotics have resulted in drug resistance. Reserving antibiotics and other antimicrobials is a promising way to combat these pathogens. Despite the antimicrobial surfaces that have been presented in the report having an intricate and prolonged synthetic process, their application is severely obstructed in practicality. For the new antibacterial nanocomposite, cerium metal-organic frameworks (Ce-MOF) that are ultrasmall in size, along with high stability, were developed as a vancomycin drug delivery system. The composite's pH-responsive synergistic antibacterial mechanism enables controlled release of vancomycin. According to the study, Ce-MOF@ Vanc can take advantage of its reversible Ce3 +/Ce4+ conversion to play a role in different physiological microenvironments, while exhibiting excellent biocompatibility. The Ce-MOF@ Vanc composite was strongly bonded to titanium alloy surfaces due to the adhesive properties of dopamine. This series of coatings exhibited highly effective antibacterial performance against S. aureus and E. coli, attributable to the synergistic action of Ce-MOF and vancomycin in membrane disruption and biochemical inhibition. The most effective coating was found to have an antibacterial efficiency of 96.62%. It showed excellent durability and corrosion resistance properties from wear and electrochemical tests. Also, the TCMV 3 coating had the highest corrosion inhibition efficiency, which was 93.22%. As a result of this research work, a new strategy was given, and an experimental basis was provided for the development of next-generation intelligent implant surfaces with the function of anti-bacteria, anti-corrosion, and biosafety.