ROS-Balancing MXene/MoSe2 Hybrids Combat Drug-Resistant Bacteria and Accelerate Tissue Regeneration in Cutaneous Wounds.

Multidrug-resistant (MDR) bacterial infections and persistent oxidative stress exert a prolonged, hostile inflammatory pressure in chronic skin wounds, posing a formidable clinical challenge. Current antibiotic-based modalities often fall short in inflammation resolution and cutaneous regeneration. Here, we present the design of a reactive oxygen species (ROS)-balancing MXene/MoSe2 (MX/Mo), with MoSe2 synthesized on MXene surfaces via a solvothermal method. In infections, MX/Mo under ultrasound activation promotes efficient electron-hole separation to trigger a localized ROS storm. This disturbs the bacterial respiratory chain and irreversibly blocks adenosine triphosphate synthesis, causing lethal energy deprivation and MDR bacterial eradication. During healing, MX/Mo without ultrasound exhibits significant multienzyme-like activity to autonomously scavenge residual ROS, alleviating oxidative injury. In in vivo studies, MX/Mo exhibits superior antibacterial and wound healing efficacy by rapidly suppressing severe Methicillin-resistant Staphylococcus aureus infections and creating a favorable microenvironment with balanced ROS levels, thereby triggering angiogenesis and promoting collagen deposition for tissue regeneration. We anticipate that MX/Mo addresses skin wounds with multifactorial pathologies by integrating antibacterial activity and oxidative stress regulation, which offers new possibilities for treating a broad range of bacterial infection-driven disorders.