Rapid communications in mass spectrometry : RCM · 2025
Surface Ionization of Carbaryl, Papaverine, Cocaine, Morphine, and Triethylamine by Heated Surface-Oxidized Metal Filaments of W, Re, Pd, Mo, Ti, and SUS304 Under Atmospheric Pressure: Ionization Mechanism.
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Hiraoka Kenzo, Usmanov Dilshadbek T, Akhmedov Sherzod M, Rankin-Turner Stephanie, Ninomiya Satoshi
Аннотация
RATIONALE: The objective of the present study is to investigate the ionization mechanisms for atmospheric pressure surface ionization (APSI).
METHODS: APSI of carbaryl, papaverine, cocaine, morphine, and triethylamine using heated surface-oxidized metal filaments of W, Re, Pd, Mo, Ti, and SUS304 were measured by mass spectrometry. Low-volatility analytes dissolved in methanol were desorbed by Leidenfrost phenomenon-assisted thermal desorption and introduced to the heated metal filament used as an emitter. Alkylamine benzene solutions were simply placed 10 mm below the filament.
RESULTS: Carbaryl, papaverine, cocaine, and morphine (M) gave protonated molecules [M+H]+ with little fragment ions. Triethylamine (TEA) gave both [TEA+H]+ and [TEA-H]+.
CONCLUSION: Because [M+H]+ was detected with little [M-H]+, which is usually detected as a major ion by vacuum surface ionization (VSI), it was concluded that [M+H]+ is formed by the proton transfer reaction between the protonated filament surface and the gas-phase analyte molecules approaching the solid surface. Namely, the heated metal filament acts as a Brønsted acid. This idea is supported by the APSI for TEA.
METHODS: APSI of carbaryl, papaverine, cocaine, morphine, and triethylamine using heated surface-oxidized metal filaments of W, Re, Pd, Mo, Ti, and SUS304 were measured by mass spectrometry. Low-volatility analytes dissolved in methanol were desorbed by Leidenfrost phenomenon-assisted thermal desorption and introduced to the heated metal filament used as an emitter. Alkylamine benzene solutions were simply placed 10 mm below the filament.
RESULTS: Carbaryl, papaverine, cocaine, and morphine (M) gave protonated molecules [M+H]+ with little fragment ions. Triethylamine (TEA) gave both [TEA+H]+ and [TEA-H]+.
CONCLUSION: Because [M+H]+ was detected with little [M-H]+, which is usually detected as a major ion by vacuum surface ionization (VSI), it was concluded that [M+H]+ is formed by the proton transfer reaction between the protonated filament surface and the gas-phase analyte molecules approaching the solid surface. Namely, the heated metal filament acts as a Brønsted acid. This idea is supported by the APSI for TEA.