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DOI 10.1016/j.waojou.2019.100080

Медицинская библиотека · The World Allergy Organization journal · 2020

IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.

Ansotegui Ignacio J, Melioli Giovanni, Canonica Giorgio Walter, Caraballo Luis, Villa Elisa, Ebisawa Motohiro, Passalacqua Giovanni, Savi Eleonora, Ebo Didier, Gómez R Maximiliano, Luengo Sánchez Olga, Oppenheimer John J, Jensen-Jarolim Erika, Fischer David A, Haahtela Tari, Antila Martti, Bousquet Jean J, Cardona Victoria, Chiang Wen Chin, Demoly Pascal M, DuBuske Lawrence M, Ferrer Puga Marta, Gerth van Wijk Roy, González Díaz Sandra Nora, Gonzalez-Estrada Alexei, Jares Edgardo, Kalpaklioğlu Ayse Füsun, Kase Tanno Luciana, Kowalski Marek L, Ledford Dennis K, Monge Ortega Olga Patricia, Morais Almeida Mário, Pfaar Oliver, Poulsen Lars K, Pawankar Ruby, Renz Harald E, Romano Antonino G, Rosário Filho Nelson A, Rosenwasser Lanny, Sánchez Borges Mario A, Scala Enrico, Senna Gian-Enrico, Sisul Juan Carlos, Tang Mimi L K, Thong Bernard Yu-Hor, Valenta Rudolf, Wood Robert A, Zuberbier Torsten

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Аннотация

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Для цитирования: Ansotegui Ignacio J, Melioli Giovanni, Canonica Giorgio Walter, Caraballo Luis, Villa Elisa, Ebisawa Motohiro, Passalacqua Giovanni, Savi Eleonora, Ebo Didier, Gómez R Maximiliano, Luengo Sánchez Olga, Oppenheimer John J, Jensen-Jarolim Erika, Fischer David A, Haahtela Tari, Antila Martti, Bousquet Jean J, Cardona Victoria, Chiang Wen Chin, Demoly Pascal M, DuBuske Lawrence M, Ferrer Puga Marta, Gerth van Wijk Roy, González Díaz Sandra Nora, Gonzalez-Estrada Alexei, Jares Edgardo, Kalpaklioğlu Ayse Füsun, Kase Tanno Luciana, Kowalski Marek L, Ledford Dennis K, Monge Ortega Olga Patricia, Morais Almeida Mário, Pfaar Oliver, Poulsen Lars K, Pawankar Ruby, Renz Harald E, Romano Antonino G, Rosário Filho Nelson A, Rosenwasser Lanny, Sánchez Borges Mario A, Scala Enrico, Senna Gian-Enrico, Sisul Juan Carlos, Tang Mimi L K, Thong Bernard Yu-Hor, Valenta Rudolf, Wood Robert A, Zuberbier Torsten. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.. The World Allergy Organization journal. 2020. DOI: 10.1016/j.waojou.2019.100080.
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