Acta obstetricia et gynecologica Scandinavica · 2010
Prevention of ovarian hyperstimulation syndrome in a rat model: efficacy comparison between cabergoline and meloxicam.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Saylan Arif, Arioz Dagistan Tolga, Koken Tulay, Dilek Husniye, Saylan Filiz, Yilmazer Mehmet
Аннотация
OBJECTIVE: To compare the efficacy of cabergoline (Cb2) and meloxicam in curbing vascular endothelial growth factor (VEGF) expression and preventing ovarian hyperstimulation syndrome (OHSS).
DESIGN: Randomized controlled, animal study.
SETTING: Academic facility.
SAMPLE: We used a total of 50 immature Wistar female rats randomly to create an experimental OHSS model.
METHODS: Ten rats each formed the control group and mild OHSS group. The remaining 30 were separated into three equal groups of severe OHSS. Mild and severe OHSS were induced through ovarian stimulation with gonadotropins. One group with severe OHSS was administered a low-dose 100 microg/kg Cb2 therapy; another group with severe OHSS received 600 microg/kg meloxicam. Body weight, vascular permeability (VP), VEGF expression, ovary weight, and diameter were then compared.
MAIN OUTCOME MEASURES: The efficacy of Cb2 and meloxicam for preventing OHSS.
RESULTS: Comparison of the severe OHSS groups with the controls and mild OHSS group revealed significant increases in VEGF expression, VP, ovary weight, and diameter. The increase in VEGF expression was demonstrated to be dependent on human chorionic gonadotropin doses. However, low-dose Cb2 and meloxicam therapies were shown to be ineffective in decreasing VEGF expression and VP, ovary weight, and ovary diameter in severe OHSS.
CONCLUSIONS: VEGF elevation played a critical part in OHSS pathogenesis, but the therapies administered failed to curb VEGF expression.
DESIGN: Randomized controlled, animal study.
SETTING: Academic facility.
SAMPLE: We used a total of 50 immature Wistar female rats randomly to create an experimental OHSS model.
METHODS: Ten rats each formed the control group and mild OHSS group. The remaining 30 were separated into three equal groups of severe OHSS. Mild and severe OHSS were induced through ovarian stimulation with gonadotropins. One group with severe OHSS was administered a low-dose 100 microg/kg Cb2 therapy; another group with severe OHSS received 600 microg/kg meloxicam. Body weight, vascular permeability (VP), VEGF expression, ovary weight, and diameter were then compared.
MAIN OUTCOME MEASURES: The efficacy of Cb2 and meloxicam for preventing OHSS.
RESULTS: Comparison of the severe OHSS groups with the controls and mild OHSS group revealed significant increases in VEGF expression, VP, ovary weight, and diameter. The increase in VEGF expression was demonstrated to be dependent on human chorionic gonadotropin doses. However, low-dose Cb2 and meloxicam therapies were shown to be ineffective in decreasing VEGF expression and VP, ovary weight, and ovary diameter in severe OHSS.
CONCLUSIONS: VEGF elevation played a critical part in OHSS pathogenesis, but the therapies administered failed to curb VEGF expression.
Предметные рубрики MeSH
Analysis of VarianceAnimalsBiopsy, NeedleBody WeightCabergolineChorionic GonadotropinDisease Models, AnimalDose-Response Relationship, DrugDrug Administration ScheduleErgolinesFemaleImmunohistochemistryInjections, IntramuscularMeloxicamOrgan SizeOvarian Hyperstimulation SyndromeOvaryOvulation InductionPregnancyPregnancy, AnimalProbabilityRandom AllocationRatsRats, WistarThiazinesThiazolesVascular Endothelial Growth Factor A