Advances in Antiarrhythmic Drug Therapy: Potentials and Challenges.

Antiarrhythmic drug therapy continues to be the cornerstone of management of both atrial and ventricular arrhythmias. Advances in the field were slowed by regulatory, scientific, clinical, and economic barriers. This review outlines the impediments to antiarrhythmic drug innovation and explores future therapies, including novel delivery platforms, atrial-selective drugs, and hybrid approaches. As the global prevalence of arrhythmias continues to rise, renewed investment in patient-centered, mechanism-driven pharmacotherapy is essential to complement existing procedural options and improve long-term outcomes.