Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
Transcranial magneto-acoustic stimulation suppresses the power and coherence of beta-oscillations in parkinsonian rat model with improvement motor performance.
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Zhang Shuai, Fan Ruiyang, Lv Jiangwei, Xu Yihao, Mi Jinrui, Wang Qingzhao, Zhang Haochen, Xu Guizhi
Аннотация
OBJECTIVE: Transcranial magneto-acoustic stimulation (TMAS) is an innovative non-invasive technique designed for neural modulation, utilizing coupled magnetic and acoustic fields to regulate brain neural activity. Alterations in the electrophysiological activity between the motor cortex (MC) and subthalamic nucleus (STN) are implicated in the motor impairments of Parkinson's disease (PD).
METHOD: This study aimed to investigate the alterant electrophysiological activities in the STN-MC pathway. Using TMAS on the STN of PD rats, changes in beta-frequency(12-30 Hz) power and coherence in the motor cortex and subthalamic nucleus were recorded and analyzed.
RESULTS: The results revealed elevated beta-band power in both STN and MC of PD rats, along with increased beta-band coherence between these regions.
CONCLUSION: Following TMAS, there was a decrease in beta-band power and phase coherence, correlating with improved spontaneous movement and motor coordination in the PD rats.
SIGNIFICANCE: These findings suggest that TMAS applied to the subthalamic nucleus of PD rats rectifies abnormal electrophysiological activities between the STN and MC, laying groundwork for future investigations.
METHOD: This study aimed to investigate the alterant electrophysiological activities in the STN-MC pathway. Using TMAS on the STN of PD rats, changes in beta-frequency(12-30 Hz) power and coherence in the motor cortex and subthalamic nucleus were recorded and analyzed.
RESULTS: The results revealed elevated beta-band power in both STN and MC of PD rats, along with increased beta-band coherence between these regions.
CONCLUSION: Following TMAS, there was a decrease in beta-band power and phase coherence, correlating with improved spontaneous movement and motor coordination in the PD rats.
SIGNIFICANCE: These findings suggest that TMAS applied to the subthalamic nucleus of PD rats rectifies abnormal electrophysiological activities between the STN and MC, laying groundwork for future investigations.