New insights into prostate cancer progression: A focus on vitamin D signaling.

Prostate cancer (PCa) is one of the most frequent cancer in men of western society. Whereas the therapeutic options for localized PCa are efficient, those for advanced forms lead to resistance and are of a poor outcome. Thus, it is of utmost importance to understand the mechanisms underlying PCa progression to identify biomarkers predicting tumor evolution and novel therapeutic options. This review summarizes the current knowledge on PCa progression, treatments and preclinical approaches, with a specific emphasis on the role of vitamin D signaling.