BMC pregnancy and childbirth · 2026
Isolation, prevalence, and antimicrobial resistance profiles of Ureaplasma spp. and Mycoplasma hominis in cervical secretions from pregnant and postpartum women in Hangzhou, China.
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Ye Jiaming, Xuan Xiaofang, Xu Ke, Ye Meizhen
Аннотация
OBJECTIVE: To evaluate the prevalence and antimicrobial resistance profiles of Ureaplasma spp. and Mycoplasma hominis in cervical secretions samples from pregnant and postpartum women in Hangzhou, China.
METHODS: We performed a retrospective analysis of Ureaplasma spp. and Mycoplasma hominis culture positive rates and antimicrobial susceptibility patterns using 1,177 cervical secretion specimens, including 616 from pregnant women, 150 from postpartum women, and 411 from asymptomatic non-pregnant women attending routine gynecological check-ups. All secretion specimens were collected at Zhejiang Provincial People's Hospital clinical microbiology laboratory between January 2017 and July 2023.
RESULTS: Among 1,177 participants, the overall genital mycoplasma (Ureaplasma spp. and Mycoplasma hominis) colonization rate was 51.60% (607/1,177), with significantly higher prevalence in pregnant women (57.10%, 352/616) compared to other groups. The highest colonization rate occurred in pregnant adolescents < 20 years (66.70%, 4/6). Ureaplasma spp. was the predominant detected species (51.50%, 317/616 in pregnant women), while M. hominis colonization was rare (≤ 0.80% overall). Co-colonization (Ureaplasma spp. + M. hominis) was detected in 4.90% (30/616) of pregnant women. The highest in vitro resistance rates among all genital mycoplasma-positive isolates (Ureaplasma spp. and Mycoplasma hominis) were observed for gatifloxacin (80.26%, 122/152), ciprofloxacin (69.17%, 184/266), and roxithromycin (37.70%, 92/244).
CONCLUSION: Ureaplasma spp. was the predominant genital mycoplasma colonizing pregnant and postpartum women in Hangzhou, with the highest rate observed among those under 20 years of age. There was high in vitro resistance to commonly used antibiotics such as ciprofloxacin and roxithromycin among the isolates. These findings provide local epidemiologic and antimicrobial susceptibility data for pregnant and postpartum women and highlight the need for further multi-center studies to confirm regional resistance patterns and clarify their clinical implications, including when genital mycoplasma colonization may warrant intervention.
METHODS: We performed a retrospective analysis of Ureaplasma spp. and Mycoplasma hominis culture positive rates and antimicrobial susceptibility patterns using 1,177 cervical secretion specimens, including 616 from pregnant women, 150 from postpartum women, and 411 from asymptomatic non-pregnant women attending routine gynecological check-ups. All secretion specimens were collected at Zhejiang Provincial People's Hospital clinical microbiology laboratory between January 2017 and July 2023.
RESULTS: Among 1,177 participants, the overall genital mycoplasma (Ureaplasma spp. and Mycoplasma hominis) colonization rate was 51.60% (607/1,177), with significantly higher prevalence in pregnant women (57.10%, 352/616) compared to other groups. The highest colonization rate occurred in pregnant adolescents < 20 years (66.70%, 4/6). Ureaplasma spp. was the predominant detected species (51.50%, 317/616 in pregnant women), while M. hominis colonization was rare (≤ 0.80% overall). Co-colonization (Ureaplasma spp. + M. hominis) was detected in 4.90% (30/616) of pregnant women. The highest in vitro resistance rates among all genital mycoplasma-positive isolates (Ureaplasma spp. and Mycoplasma hominis) were observed for gatifloxacin (80.26%, 122/152), ciprofloxacin (69.17%, 184/266), and roxithromycin (37.70%, 92/244).
CONCLUSION: Ureaplasma spp. was the predominant genital mycoplasma colonizing pregnant and postpartum women in Hangzhou, with the highest rate observed among those under 20 years of age. There was high in vitro resistance to commonly used antibiotics such as ciprofloxacin and roxithromycin among the isolates. These findings provide local epidemiologic and antimicrobial susceptibility data for pregnant and postpartum women and highlight the need for further multi-center studies to confirm regional resistance patterns and clarify their clinical implications, including when genital mycoplasma colonization may warrant intervention.