A review of the traditional uses, chemical compounds, pharmacological effects and modern clinical applications of Dahuang Huanglian Xiexin Decoction.

Dahuang Huanglian Xiexin Decoction (DHXD) is a classic traditional Chinese medicine formula renowned for its effects in clearing heat, detoxifying, and promoting bowel movement. While traditionally used for syndromes characterized by abdominal fullness and fever, DHXD has garnered significant interest for its potential in modern therapeutics. This review systematically summarizes the current knowledge on DHXD, encompassing its traditional applications, chemical constituents, pharmacological activities, and clinical uses. To date, 122 chemical compounds have been identified from DHXD, including representative components such as anthraquinones (e.g., emodin), flavonoids (e.g., baicalein), and alkaloids (e.g., berberine). These compounds contribute to its diverse pharmacological profile, particularly its anti-inflammatory, antioxidant, and metabolic-regulating activities, which underpin its growing application in managing type 2 diabetes, gastrointestinal disorders, and cardiovascular diseases. However, further research is imperative to address existing gaps in quality control standards, toxicological assessments, and detailed mechanistic studies. This review highlights the therapeutic potential of DHXD and identifies critical directions for future research to ensure its safer and more evidence-based clinical application.