International urology and nephrology · 2026
Effect of probiotic and synbiotic administration on the nutritional status of hemodialysis patients: a randomized-controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Saad Walaa M, Moheb Yara, Wafa Ehab, Elhadedy Muhammed A, Sobh Mohamed A
Аннотация
PURPOSE: Malnutrition affects up to 54% of hemodialysis patients and is associated with increased mortality. We evaluated the effects of probiotic and synbiotic supplementation on nutritional status in maintenance hemodialysis patients.
METHODS: This single-blind randomized-controlled trial enrolled 60 hemodialysis patients randomly assigned to receive Lactobacillus plantarum (10 billion CFU twice daily), synbiotic (L. plantarum plus 3 g oat fiber β-glucans daily), or standard care for 24 weeks. Primary outcomes included triceps skinfold thickness, normalized protein catabolic rate (nPCR), and body mass index (BMI). Secondary outcomes included serum albumin, total protein, cholesterol, and leptin.
RESULTS: All 60 patients completed the trial. Triceps skinfold thickness increased significantly in the probiotic group (3.3 ± 2.2 mm) and synbiotic group (4.7 ± 2.2 mm) compared to placebo (0.0 ± 1.6 mm, p < 0.001). BMI increased more in treatment groups (probiotic: 1.4 ± 1.0 kg/m2; synbiotic: 1.7 ± 0.4 kg/m2) than in the placebo group (0.7 ± 0.9 kg/m2, p < 0.001). The probiotic group showed a significant within-group increase in albumin (0.25 ± 0.37 g/dL, p = 0.008), though between-group differences were not significant. No significant changes occurred in nPCR, total protein, cholesterol, or leptin. No serious adverse events were reported.
CONCLUSION: Probiotic and synbiotic supplementation safely and effectively improved anthropometric nutritional markers in hemodialysis patients, representing feasible adjunctive strategies for managing malnutrition.
TRIAL REGISTRATION: ClinicalTrials.gov NCT06891105 (prospectively registered April 2025).
METHODS: This single-blind randomized-controlled trial enrolled 60 hemodialysis patients randomly assigned to receive Lactobacillus plantarum (10 billion CFU twice daily), synbiotic (L. plantarum plus 3 g oat fiber β-glucans daily), or standard care for 24 weeks. Primary outcomes included triceps skinfold thickness, normalized protein catabolic rate (nPCR), and body mass index (BMI). Secondary outcomes included serum albumin, total protein, cholesterol, and leptin.
RESULTS: All 60 patients completed the trial. Triceps skinfold thickness increased significantly in the probiotic group (3.3 ± 2.2 mm) and synbiotic group (4.7 ± 2.2 mm) compared to placebo (0.0 ± 1.6 mm, p < 0.001). BMI increased more in treatment groups (probiotic: 1.4 ± 1.0 kg/m2; synbiotic: 1.7 ± 0.4 kg/m2) than in the placebo group (0.7 ± 0.9 kg/m2, p < 0.001). The probiotic group showed a significant within-group increase in albumin (0.25 ± 0.37 g/dL, p = 0.008), though between-group differences were not significant. No significant changes occurred in nPCR, total protein, cholesterol, or leptin. No serious adverse events were reported.
CONCLUSION: Probiotic and synbiotic supplementation safely and effectively improved anthropometric nutritional markers in hemodialysis patients, representing feasible adjunctive strategies for managing malnutrition.
TRIAL REGISTRATION: ClinicalTrials.gov NCT06891105 (prospectively registered April 2025).