Infection and drug resistance · 2025
Predictors of Serological Cure in Syphilis Patients: A Retrospective Study at a Tertiary Hospital in Bandung, Indonesia.
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Achdiat Pati Aji, Rowawi Rasmia, Pujiastuti Nindayu Rizki, Amalia Fatimah, Suwarsa Oki, Anandita Rafithia, Maharani Retno Hesty
Аннотация
INTRODUCTION: Syphilis is an infection caused by the spirochete Treponema pallidum and transmitted through sexual intercourse. Regular monitoring is necessary to ensure affected patients have successfully attained a serological cure following medication. Despite receiving suitable medication, specific individuals in clinical settings do not succeed in achieving serological cure.
PURPOSE: This study aims to determine the factors associated with the serological cure of syphilis at Dr Hasan Sadikin General Hospital Bandung, Indonesia.
MATERIAL AND METHODS: The study procedures were carried out using a retrospective descriptive method. Secondary data were obtained from medical records at the Dermatology and Venereology Outpatient Clinic of Hasan Sadikin Hospital, Bandung, Indonesia, from 1 January 2018 to 31 December 2022.
RESULTS: The sample population comprised 266 cases of syphilis, consisting of 185 male and 81 female patients. The bivariate analysis results showed that patients aged less than 35 years had a serological cure rate of 75.4%, with a 3.89 times higher chance of achieving serological cure compared to those ≥35 years (p < 0.0001, OR = 3.89, 95% CI 1.85-8.13). In addition, the proportion of serological cure was higher in patients with Venereal disease research laboratory test (VDRL) titers of ≤1:8 before therapy (OR = 0.61, 95% CI 0.28-1.35, P = 0.226). Similar results were also obtained in those with HIV-negative (OR = 0.83, 9% CI 0.38-1.81, P=0.648), and benzathine penicillin G therapy (OR = Reff, P = 0.226).
CONCLUSION: An age of <35 years was a highly influential factor in the success of syphilis therapy. This indicates that intervention and monitoring strategies should focus on this age group, especially in resource-limited settings. The most common time for serological cure in early syphilis was the 9th and 12th months, while the 3rd and 12th months were common in late syphilis.
PURPOSE: This study aims to determine the factors associated with the serological cure of syphilis at Dr Hasan Sadikin General Hospital Bandung, Indonesia.
MATERIAL AND METHODS: The study procedures were carried out using a retrospective descriptive method. Secondary data were obtained from medical records at the Dermatology and Venereology Outpatient Clinic of Hasan Sadikin Hospital, Bandung, Indonesia, from 1 January 2018 to 31 December 2022.
RESULTS: The sample population comprised 266 cases of syphilis, consisting of 185 male and 81 female patients. The bivariate analysis results showed that patients aged less than 35 years had a serological cure rate of 75.4%, with a 3.89 times higher chance of achieving serological cure compared to those ≥35 years (p < 0.0001, OR = 3.89, 95% CI 1.85-8.13). In addition, the proportion of serological cure was higher in patients with Venereal disease research laboratory test (VDRL) titers of ≤1:8 before therapy (OR = 0.61, 95% CI 0.28-1.35, P = 0.226). Similar results were also obtained in those with HIV-negative (OR = 0.83, 9% CI 0.38-1.81, P=0.648), and benzathine penicillin G therapy (OR = Reff, P = 0.226).
CONCLUSION: An age of <35 years was a highly influential factor in the success of syphilis therapy. This indicates that intervention and monitoring strategies should focus on this age group, especially in resource-limited settings. The most common time for serological cure in early syphilis was the 9th and 12th months, while the 3rd and 12th months were common in late syphilis.